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August 18, 2024
While immunotherapy shows remarkable results in treating skin cancer, the burden of immune-related adverse events (irAEs) is a factor to weigh when considering the use of these regimens, particularly in the adjuvant and neoadjuvant settings. Why do some patients experience severe irAEs with immunotherapy? In a recent paper, researchers at NYU Langone identified a gene signature ( ie, enrichment in a gene called spleen tyrosine kinase) in immune cells at baseline in patients who experienced severe irAEs after receiving ipilimumab /nivolumab in the post-surgical setting. Efforts like this to find biomarkers to support therapeutic decision making regarding immunotherapy are critical to optimize outcomes.
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