Just tossing another consideration into the ring. When patients develop rash and or itching, we typically recommend anti-histamine therapy to manage mild to moderate grading of this adverse event. Rash +/- itching can occur early, recur often and can be a prolonged experience which may warrant frequent and possibly prolonged intervention. Anti-histamines can by drying, especially to the oral mucosa, this added dryness could potentially accelerate dental issues. This is not the norm but it could be an experince of a small subset. Any at risk patients should consider partaking in regular dental checkups.