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  • #4570

    Have you seen any instances of ocular herpes in a T-VEC treated patient?

    #4576
    Expert Nurse
    Avatar photoKrista Rubin

      I have not; though admittedly our experience with T-Vec is fairly limited at this time.

      #4579
      Expert Nurse
      Avatar photoVirginia Seery

        I have not seen any ocular herpes and we have been doing T-VEC routinely for about two years. I have had two patients develop occasional canker sores during therapy, but both of them had a history of this before starting T-VEC.

        #4583
        Expert Nurse
        Avatar photoKathleen Madden

          We too have had limited experience with T-VEC but of those patients, the only AE’s we observed were more consistent with flu like symptoms which were treated with benadryl, acetaminophen & sometimes prednisone, but typically for the first 24 hours after the injection. Regarding ocular herpes, my experiences with this is a compication typically associated with an outbreak of shingles along the ophthalmic or maxiallary dermatome which has impacted the eye, but none of these were related to T-Vec. It is possible to aquire a localized herpetic infection from other sources of contact.

          #4588
          Expert Nurse
          Avatar photoKrista Rubin

            Curious to hear how others would handle:

            Would your practice consider TVEC for a patient with a HISTORY OF recurrent herpetic infections (including ocular) that required daily suppression?

            #4589
            Expert Nurse
            Avatar photoLisa Kottschade

              Hi Krista-

              That is a very interesting question. I think this would be a difficult situation and I would want to reserve this treatment for a setting where other therapies have failed. I would not absolutely rule it out.

              #4596
              Expert Nurse
              Avatar photoKrista Rubin

                Thanks Lisa. The patient has lesions that are ideal to inject…but the ocular herpes history makes me nervous. Other options are being explored.

                #4599
                Expert Nurse
                Avatar photoVirginia Seery

                  Krista, my hesitation would be the need for chronic suppression with antivirals as this could potentially decrease the efficacy of T-VEC. However, if other options are limited or exhausted, it would be reasonable to consider with close monitoring for recurrent ocular symptoms.

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