Has anyone had a patient report “ear fullness” with combo dabrafenib and trametinib or vemurafenib and cobimetinib? Pt describes it as feeling like her ears are clogged- but on exam, no wax and TMs look normal. She is quite bothered by it.
So- I had success with a daily cetirizine. It is possible she may have had a mild URI, or similar- but she experienced it both on dabrafenib + trametinib AND vem/cobi (which we needed to switch to for unrelated reasons).
Thank you for your reply Virginia I’ll let you know for get any more!